Zhuo Tang was born in 1975 in Yuechi, Sichuan province, China. He graduated from Sichuan University in applied chemistry in 1997.In 2005, he received his doctoral degree in Chengdu Institute of organic chemistry, Chinese academy of sciences. Since the summer of 2009, Dr. Tang established his lab in Chengdu Institute of Biology, Chinese academy of sciences. As an active scientist, Dr. Tang has been presiding many scientific projects funded by National Natural Science Foundation and Technology Major Project. Dr. Tang has published more than 100 SCI peer-reviewed papers in international journals as the first author and corresponding author, including 20 papers with an impact factor of 10 or more. Besides he holds more than 20 authorized patents and is focusing on the conversion of some of these patents to practical products. 

Chemical Biology of Nucleic Acids:

 1. In vitro screening and in vivo evolution of functional nucleic acids;

 2. Genetic testing technology;

 3. Design and synthesis of protein degradation drugs.

1. member of the editorial board of Scientific Reports

2. the editorial board of Chinese Journal of Applied and Environmental Biology

He has won the first prize of Anhui Provincial Science and Technology Award (ranked fifth); the second prize of National Natural Science Award (ranked fifth); the third prize of Sichuan Provincial Science and Technology Progress Award (ranked second); the Hundred Talents Program of the Chinese Academy of Sciences; the Hundred Talents Program of Sichuan Province; the Ten Thousand Talents Program of the Organization Department of the CPC Central Committee, the Young; Middle-aged Leading Talents of Science and Technology Innovation of the Ministry of Science and Technology; the May Fourth Medal of Sichuan Youth; the May Day Labor Medal of Sichuan Province, and the Advanced Worker of the Chinese Academy of Sciences.

1.Yang, G. F.; Yuan, Y.; Tian, Y.; Zhang, S. Q.; Cui, X.; Xia, B.; Li, G. X.*; Tang, Z.*, Synthesis of Chiral Sulfonimidoyl Chloride via Desymmetrizing Enantioselective Hydrolysis, J. Am. Chem. Soc. 2023, 145, 9, 5439–5446, IF5年=15.1

2. Han, M.; Zhang, S. Q.; Cui, X.; Wang, Q. W.; Li, G. X.*; Tang, Z.*, Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp(3))-H Bromination. Angew. Chem.-Int. Edit. 2022, 61, 22, e202201418, IF5年=15.3

3. Ding, S.; Chen, G.Y.*; Wei, Y. H.; Dong, J.; Du, F.; Cui, X.; Huang, X.; Tang, Z.*, Sequence-specific and multiplex detection of COVID-19 virus (SARS-CoV-2) using proofreading enzyme-mediated probe cleavage coupled with isothermal amplification. Biosens. Bioelectron. 2021, 178, 113041. IF5年=10.8

4. Zhang, S. Q.; Li, G. X.; Li, L.; Deng, X. F.; Zhao, G.*; Cui, X.; Tang, Z.*, Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen. Acs Catalysis 2020, 10 (1), 245-252. IF5年=13.3

5. Huang, X.; Chen, R.; Sun, M. L.; Peng, Y.; Pu, Q. L.; Yuan, Y.; Chen, G.Y.; Dong, J.; Du, F.; Cui, X.; Tang, Z.*, Frame-shifted proteins of a given gene retain the same function. Nucleic Acids Res. 2020, 48 (8), 4396-4404. IF5年=16.4

6. Ma, L. J.; Chen, S. S.; Li, G. X.*; Zhu, J.; Wang, Q. W.; Tang, Z.*, Chiral Bronsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity. Acs Catalysis 2019, 9 (2), 1525-1530. IF5年=13.3

7. Huang, X.; Zhao, Y.; Pu, Q.; Liu, G.; Peng, Y.; Wang, F.; Chen, G.; Sun, M.; Du, F.; Dong, J.; Cui, X.; Tang, Z.*; Mo, X., Intracellular selection of trans-cleaving hammerhead ribozymes. Nucleic Acids Res. 2019, 47 (5), 2514-2522. IF5年=16.4

8.Hu, W.; Yuan, Y.; Wang, C. H.; Tian, H. T.; Guo, A. D.; Nie, H. J.; Hu, H.; Tan, M.; Tang, Z.*; Chen, X. H.*, Genetically Encoded Residue-Selective Photo-Crosslinker to Capture Protein-Protein Interactions in Living Cells. Chem 2019, 5 (11), 2955-2968.  IF5年=25.4

9. Ding, S.; Chen, R.; Chen, G. Y.; Li, M.; Wang, J. Y.; Zou, J. W.; Du, F.; Dong, J.; Cui, X.; Huang, X.; Deng, Y.*; Tang, Z.*, One-step colorimetric genotyping of single nucleotide polymorphism using probe-enhanced loop-mediated isothermal amplification (PE-LAMP). Theranostics 2019, 9 (13), 3723-3731. IF5年=12.3

10. Chen, R.; Lu, X.; Li, M.; Chen, G.; Deng, Y.; Du, F.; Dong, J.; Huang, X.; Cui, X.; Tang, Z.*, Polymerase Chain Reaction using "V" Shape Thermal Cycling Program. Theranostics 2019, 9 (6), 1572-1579. IF5年=12.3

11. Yuan, Y.; Zhao, Y.; Chen, L.; Wu, J.; Chen, G.; Li, S.; Zou, J.; Chen, R.; Wang, J.; Jiang, F.*; Tang, Z.*, Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch. Nucleic Acids Res. 2017, 45 (15), 8676-8683. IF5年=16.4

12. Zhao, Y. Y.; Chen, H. D.; Du, F.; Yasmeen, A.; Dong, J.; Cui, X.*; Tang, Z.*, Signal amplification of glucosamine-6-phosphate based on ribozyme glmS. Biosens. Bioelectron. 2014, 62, 337-342. IF5年=10.8

13. Wang, M. Q.; Zhang, H. F.; Zhang, W.; Zhao, Y. Y.; Yasmeen, A.; Zhou, L.; Yu, X. Q.*; Tang, Z.*, In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity. Nucleic Acids Res. 2014, 42 (14), 9262-9269. IF5年=16.4

14. Zhao, Y. Y.; Zhou, L.; Tang, Z.*, Cleavage-based signal amplification of RNA. Nat. Commun. 2013, 4, 1493. IF5年=17.0

15. Dong, J.; Cui, X.; Deng, Y.*; Tang, Z.*, Amplified detection of nucleic acid by G-quadruplex based hybridization chain reaction. Biosens. Bioelectron. 2012, 38 (1), 258-263. IF5年=10.8

National Natural Science Foundation Excellent Young Scientists Fund; the National Natural Science Foundation of China (NSFC) General Project; the National Major Science and Technology Special Project; Sino-German Center for Research Promotion Sino-German Bilateral Cooperation Project; the Innovative Team Project of Sichuan Province; the Sichuan Provincial Natural Science Foundation Key Project; and the Chengdu Major Science and Technology Innovation Project.