Research

l　　　  Asymmetric organic reaction catalyzed by Organocatalyst

l　　　  Nucleic acid chemistry

l　　　  In vitro Selection of DNA cleaving DNAzyme

l　　　  Biosensor for pathogen detection based DNAzyme

l　　　  DNA display

Honors and Awards

1.　　　  2005　　　 Special Presidential Scholarship of Chinese Academy of Sciences.

2.　　　  2005　　　 One of 25 Chinese doctoral students chose to take part in the 　　　　　Meetings of Nobel Laureates in Lindau.

3.　　  2006　  Humboldt Fellowship

4.　　  2007　　　 Outstanding Thesis Awards of Chinese Academy of Sciences.

5.　　  2008　　　 One Hundred Outstanding Thesis Awards of China

6.  2009　　　 One Hundred Person Project of the Chinese Academy of Sciences

Publication

发表论文　　　 

1.　　　　  Feng Du, Zhuo Tang*. Colorimetric Detection of PCR Product with DNAzymes Induced by 5′-Nuclease Activity of DNA Polymerases.  ChembioChem. 2011, 12, 43-46. 

2.　　  Shou-Peng Liu, Samuel H. Weisbrod, Zhuo Tang, Andreas Marx, Elke Scheer, Artur  Erbe. Direct Measurement of Electrical Transport Through G-Quadruplex DNA with Mechanically Controllable Break Junction Electrodes. Angew. Chem., Int. Ed. 2010, 46, 3313-3316.

3. Zhuo Tang, Diana. P. N. Goncalves, Markus Wieland, Andreas Marx. J？rg S. Hartig. Novel DNA Catalysts based on G-quadruplex recognition. Chembiochem, 2008, 9, 1061-1064.
4. Jun-Feng Zhao , Long He, Jun Jiang, Zhuo Tang, Lin-Feng Cun, Liu-Zhu Gong. Organo-catalyzed highly diastereo- and enantio-selective direct aldol reactions in water. Tetrahedron Letters. 2008, 49, 3372-3375.
5. Xiao-Ying Xu, Zhuo Tang, Yan-Zhao Wang, Shi-Wei Luo, Lin-Feng Cun, Liu-Zhu Gong. Asymmetric Organocatalytic Direct Aldol Reactions of Ketones with α-Keto Acids and Their Application to the Synthesis of 2-Hydroxy-γ-butyrolactones. J. Org. Chem, 2007, 72, 9905-9913.
6. Xiao-Hua Chen, Shi-Wei Luo, Zhuo Tang, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang, Liu-Zhu Gong. Organocatalyzed Highly Enantioselective Direct Aldol Reactions of Aldehydes with Hydroxyacetone and Fluoroacetone in Aqueous Media: The Use of Water to Control Regioselectivity. Chemistry - A European Journal, 2007, 13, 689-701.
7. Long He, Jun Jiang, Zhuo Tang, Xin Cui, Ai-Qiao Mi, Yao-Zhong Jiang and Liu-Zhu Gong. Highly Diastereo- and Enantioselective Direct Aldol Reactions of Cycloketones with Aldehydes Catalyzed by a Trans-4-tert- butyldimethyl-siloxy-L-proline Amide. Tetrahedron Asymmetry, 2007, 18, 265-270.
8. Zhuo Tang, Andreas Marx. Proline-Modified DNA as Catalyst of the Aldol Reaction. Angew. Chem., Int. Ed. 2007, 46, 7297-7300. Prolinmodifizierte DNA als Katalysator der Aldolreaktion. Angewandte Chemie. 2007, 119, 7436-7439
9. Zhuo Tang, Xin Cui, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang, Liu-Zhu Gong. Novel Organocatalyst Bearing Molecular Recognition Group. Organic letters.; 2006; 8; 1263-1266.
10. Long He, Zhuo Tang, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang and Liu-Zhu Gong, L-Proline Amide-catalyzed Direct Asymmetric Aldol Reaction of Aldehydes with Chloroacetone. Tetrahedron, 2006, 62, 346-351.
11. Zhuo Tang, Zhi-Hua Yang, Xiao-Hua Chen, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang, Liu-Zhu Gong. Development of a Highly Efficient L-Prolinamide-Based Organocatalyst for Direct Aldol Reactions by Tuning the Electronic Property of the Substituent. J. Am. Chem. Soc.; 2005, 127; 9285-9289.　 
12. Zhuo Tang, Zhi-Hua Yang, Lin-Feng Cun, Liu-Zhu Gong, Ai-Qiao Mi, and Yao-Zhong Jiang. Small Peptides Catalyze Highly Enantioselective Direct Aldol Reactions of Aldehydes with Hydroxyacetone: Unprecedented Regiocontrol in Aqueous Media. Organic letters; 2004, 6, 2285-2287.
13. Zhuo Tang, Fan Jiang, Xin Cui, Liu-Zhu Gong, Ai-Qiao Mi, Yao-Zhong Jiang, and Yun-Dong Wu.; Enantioselective Direct Aldol Reactions Catalyzed by L-prolinamide Derivatives. Proc. Natl. Acad. Sci. USA.; 2004, 101, 5755-5760.　　
14. Zhuo Tang, Fan Jiang.; Luo-Ting Yu, Cui Xin, Liu-Zhu Gong, Ai-Qiao Mi, Yao-Zhong Jiang, Yun-Dong Wu.; Novel Small Organic Molecules for a Highly Enantioselective Direct Aldol Reaction.J. Am. Chem. Soc.;2003，125，5262-5263.

Remembers of the group

Qingquan Fu, male, Renshou, Sichuan, China.

2010-present  Chengdu Institution of Biology, Chinese Academy of Sciences, 　　　　　　　　　　　　　 research on drug synthesis.

2007-2010  Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, research on drug synthesis.

2006-2007  University of New Mexico, Organic chemistry ,Postdoctor.

2003-2006  Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Organic chemistry, Ph.D..

2000-2003  Department of Applied Chemistry, Sichuan University, Applied Chemistry, Master.

1995-1999  Department of Chemistry, Huaibei Normal University, Chemistry, Bachelor.

Email：fuqingquan@yahoo.com.cn

Xin Cui, female, Benxi, Liaoning, China.

2010-present  Chengdu Institution of Biology, Chinese Academy of Sciences. research on analytical chemistry.

2007-2010  College of Chemistry, Sichuan University, Analytical Chemistry, Master.

1998-2007  Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, research on analytical chemistry.

1993-1998  College of Chemistry, Sichuan University, Analytical Chemistry, Bachelor.

Email：cuixin@cib.ac.cn

Frank Streckenbach, male, German, 1980, Immenstaad, Baden-Württemberg, Germany.

2010-present  Chengdu Institute of Biology, Chinese Academy of Sciences, Postdoctor.

2006-2010  University Konstanz, Chemistry, Ph.D..

2001-2006  University Konstanz, Chemistry, Dipl.-Chemiker.

Email：frank.streckenbach@uni-konstanz.de

Guangxun Li, male, 1982, Luzhou, Sichuan, China

2008-present  Chengdu Institute of Biology CAS, Pharmaceutical Chemistry, Ph.D..

2005-2008  Institute of Applied Ecology CAS, Silviculture, Master.

2001-2005  Sichuan Agriculture University, Forestry, Bachelor.

Email: lidengjudeer@163.com

Haodong Chen, male, 1984, JieYang, Guangdong, China.

2009-present  Chengdu Institute of Biology, Chinese Academy of Sciences, Doctor, research on DNA Display.

2006-2009  Hunan Agricultural University, Genetics, Master.

2002-2006  Hunan Agricultural University, Biotechnology, Bachelor.

Email: chenhaodong301@163.com

Feng Du, female, 1984, MiLuo, Hunan, China.

2010-present  Chengdu Institute of Biology, Chinese Academy of Sciences, research on Nucleic acid probe and DNAzyme

2006-2009  Hunan Agricultural University, Genetics, Master.

2002-2006  XiangTan University, Bioengineering, Bachelor.

Email: radishdu@yahoo.com.cn

Juan Dong, female, 1985, Mianyang, Sichuan, China.

2010-present  Chengdu Institute of Biology, Chinese Academy of Sciences, Pharmaceutical Chemistry, Doctor., working on the catalytic reaction of photosensitized hydrogen evolution with DNAzyme.

2007-2010  Chengdu Institute of Biology, Chinese Academy of Sciences, Environmental Science, Master.

2003-2007 Zhengzhou Institute of Aeronautical Industry Management, Environment Engineering, Bachelor.

Email: dongjuan07@mails.gucas.ac.cn

Yang Mingrong, female, 1986, Chengdu, Sichuan, China.

2009-present  Sichuan University and Chengdu Institute of Biology, Chinese Academy of Sciences joint training Master, research on the synthesis of modified DNA.

2005-2009  West China School of Pharmacy Sichuan University: Pharmacy , Bachelor.

Email：YMR8633@163.com

Yongyun Zhao, female, Chinese, 1986, Liaocheng, Shandong, China.

2009-present  Chengdu Institute of Biology, Chinese Academy of Sciences, Master, research on RNA detection.

2001-2006  Shandong University of Traditional Chinese Medicine, Chinese traditional medicine, Bachelor.

Email：yongyunfly@163.com

Huafan Zhang, female, 1985, Handan, Hebei, China.

2009- present  Chengdu Institute of Biology, Chinese Academy of Sciences, Pharmaceutical Chemistry, Master, research on in vitro selection of DNAzyme.

2005-2009  Heilongjiang University of Chinese Medicine, Chinese Traditional Medicine, Bachelor.

Email：huafan_zhang2008@yahoo.com.cn

Junjie Liu, male, 1986, Jinhua, Zhejiang, China.

2009-present  Sichuan University and Chengdu Institute of Biology, Chinese Academy of Sciences, joint training Master, research on the synthesis of modified DNA.

2004-2008  Zhejiang Taizhou University, Materials Chemistry, Bachelor.

Email: sctzc@yahoo.com.cn

Rong Chen, female, 1987, Chengdu, Sichuan, China.

2010-present  Chengdu Institute of Biology, Chinese Academy of Sciences, Pharmaceutical Chemistry, Master.

2006-2010  China Pharmaceutical University，Chinese Traditional Medicine, Bachelor.

Email：cibchenrong@sina.com

Li Zhou, female, 1987, Suizhou, Hubei, China.

2010-present  Chengdu Institute of Biology, Chinese Academy of Sciences, Pharmaceutical Chemistry, Master.

2006-2010  Southwest University for Nationalities, Pharmaceutics, Bachelor.

Email：zhouli1987zs@163.com