| Details of Paper |
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| Paper Code |
DOI: 10.1002/chem.200801582 |
| Title |
Highly Enantioselective Synthesis of β-Amino Acid Derivatives by the Lewis Base Catalyzed Hydrosilylation of β-Enamino Esters |
| Authors |
Hong-Jie Zheng |
| All Authors |
Hong-Jie Zheng,Wen-Bing Chen,Zhi-Jun Wu,Jin-Gen Deng,
Wen-Qing Lin,Wei-Cheng Yuan,Xiao- Mei Zhang |
| Corresponding Author |
Xiao- Mei Zhang |
| Year |
2008 |
| Title of Journal |
Chemistry A European Journal |
| Volume |
32 |
| Number |
Hong-Jie Zheng |
| Page |
9864-9867 |
| Abstract |
Aryl substitute makes it different:A new general enantioselective hydrosilylation of N-aryl β-enamino esters with trichlorosilane has been developed (see scheme). The N-aryl substituent is crucial for the activity and enantioselectivity. In the presence of catalytic amount of readily accessible chiral N-picolinoylpyrrolidine derivatives, the reactions proceeded smoothly to provide various chiralβ-amino esters in good yields (≤97 %) and moderate to excellent enantioselectivities (≤96 % ee).
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