SELECTED RECENT PUBLICATIONS

1.　Zhang, Z.-G.; Liu, Y.; Guengerich, F.P.; Matse, J.H.; Chen J.; Wu, Z.-L.* Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries. J. Biotechnol. 2009, 139(1), 12-18.

2.　Wu, Z.-L.*; Qiao, J.; Zhang, Z.-G.; Guengerich, F.P.; Liu, Yan; Pei, X.-Q. Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpression. Biotechnol. Lett. 2009, in press. doi: 10.1007/s10529-009-0059-5

3.　Stark, K.; Wu, Z.-L.; Bartleson, C.J.; Guengerich, F.P. Heterologous expression and mRNA distribution of orphan cytochrome P450 20A1. Drug Metab. Dispos. 2008, 36(9), 1930-1937.

4.　Guengerich, F.P.; Wu, Z.-L. Biosynthesis of novel indirubins by recombinant cytochrome P450 systems. Invited chapter in Indirubin, the Red Shade of Indigo, edited by Meijer, L.; Guyard, N.; Skaltsounis, L; Eisenbrand, G. Editions <life in progress>, Roscoff, Fr. 2006, 79-87.

5.　Wu, Z.-L.; Sohl, C.D.; Shimada, T.; Guengerich, F.P. Recombinant Enzymes Over expressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1. Mol. Pharmacol. 2006, 69(6), 2007-2014.

6.　Wu, Z.-L.; Podust, L.M.; Guengerich, F.P. Expansion of Substrate Specificity of Cytochrome P450 2A6 by Random and Site-Directed Mutagenesis. J. Biol. Chem. 2005, 280(49), 41090-41100.

FINANCIAL SUPPORT

1.　National Natural Science Foundation of China 20802073/B020104 (2009.1 - 2011.12)

2.　The 100 Talents Program of the Chinese Academy of Sciences (2009.1 - 2011.12)

3.　Provincial Sci & Tech Foundation for Young Scholars of Sichuan, China 08ZQ026-023 (2008.1 - 2011.1)

4.　The Knowledge Innovation Program of the Chinese Academy of Sciences KSCX1-YW-11B2 (2008.1 - 2011.12)