Curriculum vitae

Personal dates

·　　　 Name:　　　　　 Frank Streckenbach

·　　  Adress:　　　　  No.9 Section 4,Renmin Nan Road,Chengdu, Sichuan, P.R China

·　　  eMail:　　 　　　　　 Frank.Streckenbach@uni-konstanz.de

·　　　 Nationality:　  　  German

·　　　 Family status: 　　 married

Education

• 1987 - 1991 　　　 Primary school Immenstaad
• 1991 - 2000 　　　 Graf-Zeppelin-Gymnasium Friedrichshafen

Civil service

• 2000 - 2001　　　　 Ambulance service at the Red Cross, Friedrichshafen

Academical education

• Oct 2001 - Aug. 2006　　  Studies in Chemistry, University Konstanz

　　　　　　　　　　　　　　　　　　　　　　　　　　　　 Degree: Diplom-Chemiker

• Nov. 2005 - Aug. 2006　　 Synthesis of 4’-C-alkylated DNA“ - Diploma thesis　with Prof. Andreas Marx (Chair of Organic Chemistry / Cellular Chemistry, University of Konstanz)

Ph.D.

• Nov. 2006 - Aug. 2010　　 “Kinetic Studies on Different DNA Polymerases Using 4‘-Alkylated 2‘-Deoxynucleotide Probes” - Ph.D. work with Prof. Andreas Marx (Chair of Organic

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　  Chemistry / Cellular Chemistry, University of Konstanz)

12.2002-02.2003　　　 University Konstanz, group Prof. Dr. Brintzinger

　　　　　　　　　　　　　　　　　　  Student assistant: Tutorial for 1st semester students on „general and inorganic chemistry“

08.2004-09.2004　　　 University Konstanz, group Prof. Dr. Marx

　　　　　　　　　　　　　　　　　　  Student assistant: Expression and Purification of Pfu DNA polymerase

Publication list

·　　　 F. Streckenbach, G. Rangam, H. M. Möller, A. Marx, ChemBioChem 2009, 10, 1630-1633. “Steric Constraints Dependent on Nucleobase Pair Orientation Vary in Different DNA Polymerase  Active　Sites”

·　　　 K. Betz+, F. Streckenbach+, A. Schnur, T. Exner, W. Welte, K. Diederichs, A. Marx, , Angew. Chem. Int. Ed. 2010, 49, 5181-5184. “Structures of DNA polymerases caught processing size-augmented  nucleotide probes” +equal contribution

Professional skills

Organic synthesis, solid support DNA synthesis, ESI mass spectroscopy, NMR spectroscopy, MPLC/HPLC/FPLC-systems, polyacrylamide/agarose gel electrophoresis, steady-state kinetics, pre-steady-state kinetics, site-directed mutagenesis, polymerase expression and purification

Courses and Mentoring

Regular Assistant in the Labcourse Organic Chemistry III: “Stereochemistry and Reaction Mechanisms” (2007-present)

Mentoring of Bachelor Thesis (Project: “Synthesis of 4’-C-modified-α-thio-deoxynucleotide triphosphates”) and visiting student from Canada (Project: “4’-C-modified 7-deaza-2’-deoxyadenosine”)

International Conferences with poster presentation

LMU Munich, “Synthesefest” March 2009

SDU Odense, 4th Nucleic Acid Chemical Biology (NACB) PhD Summer School June 2009

University Regensburg, Vielberth-Symposium on Functional Nucleic Acids September 2009