Education and Appointments: Sep., 1993—Jul., 1997, B. S. in Biology, School of Life Science, Southwest Normal University (SWNU), Chongqi, China Sep., 1997—Jul., 2000, M. S. in Natural Products Chemistry, Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu, China Sep., 2000—Jul., 2003, Ph. D in Organic Chemistry, Chengdu Institute of Organic Chemistry, the Chinese Academy of Sciences (CAS), Chengdu, China Apr., 2007—Apr. 2008, Visiting Scholar in Chemical Biology, University of Wisconsin-Madison, USA Research Interest Biosynthesis and synthetic biology of medicines
Public Services Honors Seleted Publication 1. Yi Li, Xuefei Wang, Zhan Liu, Yun Yang, Liangzhen Jiang, Xixing Qu, Xiang Pu, Yinggang Luo*. Regioselective O-acetylation of various glucosides catalyzed by Escherichia coli maltose O-acetyltransferase. Applied Microbiology and Biotechnology 2023, 107, 7031-7042. 2. Daijing Wei, Yun Yang, Ruiying Xi, Yunqing He, Ighodaro Igbe, Wei Wang, Guolin Zhang*, Yinggang Luo*. Hunteriasines A – D, tryptamine-derived alkaloids from Hunteria umbellata. Phytochemistry 2023, 213, 113752. 3. Zhan Liu, Yi Li, Daijing Wei, Jing Wang, Chong Qiao, Guo-you Li, Guolin Zhang and Yinggang Luo*. Biosensor-enabled discovery of CaERG6 inhibitors and their antifungal mode of action against Candida albicans. ACS Infectious Diseases 2023, 9, 785-800. 4. Chong Qiao, Fei Chen, Zhan Liu, Tianfang Huang, Wei Li, Guolin Zhang, Yinggang Luo*. Functional characterization of a catalytically promiscuous tryptophan decarboxylase from camptothecin-producing Camptotheca acuminata. Frontiers in Plant Science 2022, 13, 987348. 5. Xuejian Zhang, Yu Cao, Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang*, and Yinggang Luo*. Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa. Phytochemistry 2022, 203, 113378. 6. Xuejian Zhang, Guoyong Luo, Yu Cao, Dumaa Mishig, Munkhgerel Lodonjav, Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang,* and Yinggang Luo*. (±)-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa. Bioorganic Chemistry 2021, 116, 105364. 7. Liangzhen Jiang, Jing Pang, Lixia Yang, Wei Li, Lili Duan, Guolin Zhang, Yinggang Luo*. Engineering endogenous L-proline biosynthetic pathway to boost trans-4-hydroxy-L-proline production in Escherichia coli. Journal of Biotechnology 2021, 329, 104-117. 8. Xuejian Zhang, Ting Peng, Xiaoke Shi, Dongmei, Fang, Lin Tang, Fang Chen, Fei Wang,Guolin Zhang*, YinggangLuo*. Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa. Phytochemisty 2020, 180, 112534. 9. Annoor Awadasseid, Wei Li, Zhan Liu, Chong Qiao, Jing Pang, Guolin Zhang, Yinggang Luo*. Characterization of Camptotheca acuminata 10-hydroxygeraniol oxidoreductase and iridoid synthase and their application in biological preparation of nepetalactol in Escherichia coli featuring NADP+ - NADPH cofactors recycling. International Journal of Biological Macromolecules 2020, 162, 1076-1085. 10. Yun Yang, Wei Li, Jing Pang, Liangzhen Jiang, Xixing Qu, Xiang Pu, Guolin Zhang, and Yinggang Luo*. Bifunctional cytochrome P450 enzymes involved in camptothecin biosynthesis. ACS Chemical Biology 2019, 14, 1091-1096. 11. Wei Li, Chong Qiao, Jing Pang, Guolin Zhang, Yinggang Luo*. The versatile O-methyltransferase LrOMT catalyzes multiple O-methylation reactions in Amaryllidaceae alkaloid biosynthesis. International Journal of Biological Macromolecules 2019, 141, 680-692. 12. Jinzhi Zhao, Yun Yang, Mengyao Yu, Ke Yao, Xia Luo, Huayi Qi, Guolin Zhang*, and Yinggang Luo*. Lanostane-type C31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris. Phytochemistry 2018, 152, 10-21. 13. Wei Li, Yun Yang, Chong Qiao, Guolin Zhang, and Yinggang Luo*. Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encodiing genes from Lycoris radiata, a galanthamine-producing plant. International Journal of Biological Macromolecules, 2018, 117, 1264-1279. 14. Lixia Yang, Liangzhen Jiang, Wei Li, Yun Yang, Guolin Zhang, and Yinggang Luo*. A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial application in geraniol production in Escherichia coli. Journal of Industrial Microbiology & Biotechnology 2017, 44 (10), 1431-1441. 15. Yun Yang, Xiang Pu, Xixing Qu, Fei Chen, Guolin Zhang, and Yinggang Luo*. Enhanced production of camptothecin and biological preparation of N1-acetylkynuramine in Camptotheca acuminata cell suspension cultures. Applied Microbiology and Biotechnology 2017, 101 (10), 4053-4062. 16. Fei Chen, Wei Li, Liangzhen Jiang, Xiang Pu, Yun Yang, Guolin Zhang, and Yinggang Luo*. Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in the production of geraniol in Escherichia coli. Journal of Industrial Microbiology & Biotechnology 2016, 43 (9), 1281-1292. 17. Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guolin Zhang*, and Yinggang Luo*. Iridoid glucosides and diteropenoids from Caryopteris glutinosa. Journal of Natural Products 2016, 79 (4), 886-893. 18. Xiang Pu, Fei Chen, Yun Yang, Xixing Qu, Guolin Zhang, and Yinggang Luo*. Isolation and characterization of Paenibacillus polymyxa LY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata. Journal of Industrial Microbiology & Biotechnology 2015, 42, 1197-1202. 19. Xixing Qu, Xiang Pu, Fei Chen, Yun Yang, Lixia Yang, Guolin Zhang, and Yinggang Luo*. Molecular cloning, heterologous expression, and functional characterization of an NADPH-cytochrome P450 reductase gene from Camptotheca acuminata, a camptothecin-producing plant. PLoS ONE 2015, 10 (8), e0135397. doi: 10.1371/journal.pone.0135397. 20. Yinggang Luo*, Xiang Pu, Guoyong Luo, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Huayi Qi, Guo-you Li, and Guo-lin Zhang*. Nitrogen-containing Dihydro-b-agarofuran Derivatives from Tripterygium wilfordii. Journal of Natural Products 2014, 77 (7), 1650-1657. 21. Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang*, and Yinggang Luo*. Camptothecin-producing Endophytic Fungus Trichoderma atroviride LY357: Isolation, Identification, and Fermentation Conditions Optimization for Camptothecin Production. Applied Microbiology and Biotechnology 2013, 97 (21), 9365-9375. 22. Shou-Zheng Tian, Xiang Pu, Guoyong Luo, Li-Xing Zhao, Li-Hua Xu, Wen-Jun Li, and Yinggang Luo*. Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087. Journal of Agricultural and Food Chemistry 2013, 61 (12), 3006-3012. 23. Yinggang Luo, Min Zhou, Qi Ye, Qiang Pu, and Guolin Zhang*. Dihydroagarofuran derivatives from the dried roots of Tripterygium wilfordii. Journal of Natural Products 2012, 75 (1), 98-102. 24. Yinggang Luo*, Guangzhou Li, Guoyou Li, Jufang Yan, Jinhai Yi, and Guolin Zhang. Discovery and identification of 2-phenylethyl 2,6-dihydroxybenzoate as a natural lipid-lowering lead. Planta Medica 2011, 77 (18), 2047-2049. 25. Jianya Ling, Geoffrey P. Horsman, Sheng-Xiong Huang, Yinggang Luo, Shuangjun Lin, and Ben Shen*. Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring a C-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate. Journal of the American Chemical Society 2010, 132 (36), 12534-12536. 26. Yinggang Luo, Wenli Li, Jianhua Ju, Qiuping Yuan, Noel R. Peters, F. Michael Hoffmann, Sheng-Xiong Huang, Tim S. Bugni, Scott Rajski, Hiroyuki Osada and Ben Shen*. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. Journal of the American Chemical Society 2010, 132 (19), 6663-6671. 27. Wenli Li, Yinggang Luo, Jianhua Ju, Scott R. Rajski, Hiroyuki Osada, and Ben Shen*. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. Journal of Natural Products 2009, 72 (3), 450-459. 28. Yinggang Luo, Shuangjun Lin, Jian Zhang, Heather A. Cooke, Steven D. Bruner, and Ben Shen*. Regiospecific O-Methylation of Naphthoic Acids Catalyzed by NcsB1, an O-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin. The Journal of Biological Chemistry 2008, 283, 14694-14702. Supported Projects Sponsored by National Natural Science Foundation of China, Chinese Academy of Sciences, Sichuan Province, Chengdu city and etc.
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