Education and Appointments: Dr. Xun Liao was born in Chengdu, Sichuan Province in Nov. 1972. He has been working in Chengdu Institute of Biology, CAS, after obtaining his PhD degree from Department of Chemistry, Zhejiang University in 2000. He was selected for the “West Light” Talent Program of the Chinese Academy of Sciences in 2010. He once served as a member of the Basic Theory Committee of the Chinese Society of Integrative Medicine, and currently is a senior member of the Chinese Chemical Society. He is a reviewer for more than 20 international academic journals, and currently serves an editorial board member of the journal Plants. He has undertaken more than 30 scientific research projects, has more than 100 research papers published and 9 patents granted. His research interests lie in the natural product chemistry and bioorganic analysis. He proposed the strategy of "ligand fishing" for accelerating the discovery of new natural active compounds for developments of new drugs and health products such as nutraceuticals and cosmeceuticals. The ligand fishing methods are developed based on functionalized magnetic beads, carbon quantum dots, cell surface display, and microfluidic chips. In recent years, his team is focusing on the medicinal and edible plants possessing anti-Parkinson's disease and anti-photoaging effects by using the "ligand fishing" technique in combination with biological assays. Research Interest Natural product chemistry Public Services Honors Seleted Publication 1. YK Hu, A Ablat, XL Bai, X Yin, C Ma, X Liao*. Phenolamides from rootstocks of Lycium ruthenicum Murr by ligand fishing and their neuroprotective effects. Journal of Agricultural and Food Chemistry, 2025, https://doi.org/10.1021/acs.jafc.4c11099. 2. YK Hu, C Ma, MJ Li, XL Bai, YM Liu*, X Liao*. Screening of monoamine oxidase B inhibitors in Tibetan strawberry by ligand fishing based on enzyme functionalized cellulose filter paper. Microchemical Journal, 2024, https://doi.org/10.1016/j.microc.2024.110838. 3. YK Hu, XL Bai, GY Shi, YM Zhang*, X Liao*. Polyphenolic glycosides with unusual four-membered ring possessing anti-Parkinson’s disease potential from black wolfberry. Phytochemistry, 2023, 213: 113775. 4. YK Hu, YM Liu, XL Bai, C Ma*, X Liao*. Screening of monoamine oxidase B inhibitors from Fragaria nubicola by ligand fishing and their neuroprotective effects. Journal of Agricultural and Food Chemistry, 2023, 71: 512–521. 5. XL Bai, YJ Luo, WQ Fan, YM Zhang*, X. Liao*. Neuroprotective effects of Lycium barbarum fruit extract on Pink1B9 Drosophila melanogaster genetic model of Parkinson's disease. Plant Foods for Human Nutrition, 2023,78: 68-75. 6. YK Hu, XL Bai, H Yuan, Y Zhang, X Liao*. Polyphenolic glycosides from the fruits extract of Lycium ruthenicum Murr and their monoamine oxidase B inhibitory and neuroprotective activities. Journal of Agricultural and Food Chemistry, 2022, 70:7968-7980. 7. YC Yuan, XL Bai, YM Liu*, XY Tang, H Yuan, X Liao*. Ligand fishing based on cell surface display of enzymes for inhibitor screening, Analytica Chimica Acta, 2021, 1156: 338359. 8. XY Tang, YM Liu*, XL Bai, H Yuan, YK Hu, XP Yu, X Liao*. Turn-on fluorescent probe for dopamine detection in solutions and live cells based on in situ formation of aminosilane-functionalized carbon dots. Analytica Chimica Acta, 2021，1157: 338394. 9. XL Jiang, YC Yuan, LB Chen, YM Liu*, MW Xiao, YD Hu, Z Chun, X Liao*. Monoamine oxidase B immobilized on magnetic nanoparticles for screening. Microchemical Journal, 2019, 146:1181-1189. Supported Projects 1. Research and development of polypeptides with anti-Parkinson's disease activity in Dilong, Sichuan Province Key Research and Development Project，2023.1–2024.12 2. Systematic mining, development and utilization of bioactive components in Salvia miltiorrhizae, Major Science and Technology Innovation Project of Chinese Academy of Sciences-Chengdu City Science and Technology Co-operation. 2021.12–2023.11 3. Surface display technology for the study of hypoglycemic active ingredients in medicinal plants, Sichuan Province Application Basic Key Research project，2017.1–2019.12 4. Establishment of natural compounds targeting Parkinson's disease proteins and screening for lead compounds，Chinese Academy of Sciences Strategic Bioresources Service Network Program, 2016.11–2018.6 5. Application of microfluidic chip electrophoresis-mass spectrometry methodology in the study of primordial germ cell development, "West Light" talent Scholarship Program, 2015.1–2018.12 6. Screening of small molecule enzyme inhibitors in traditional Chinese medicine with fluorescent magnetic nanoparticle probe, The National Natural Science Foundation of China, 2011.1–2015.12 7. Magnetic nanoparticle-based microsomal bioreactor for metabolic studies of traditional Chinese medicine, The National Natural Science Foundation of China, 2010.1–2013.12 8. Ligand fishing of active ingredients in traditional Chinese medicine by magnetic nanoparticle solid-phase extraction (SPE), The National Natural Science Foundation of China, 2008.1–2010.12
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