Dr. Xun Liao, born in Chengdu, Sichuan Province in Nov. 1972. After obtaining the PhD degree from Department of Chemistry, Zhejiang University in 2000, I began to work in Chengdu Institute of Biology, Chinese Academy of Sciences. I was selected for the “West Light” Talent Program of the Chinese Academy of Sciences, and served as a member of the Basic Theory Committee of the Chinese Society of Integrative Medicine, and currently senior member of the Chinese Chemical Society and editorial board member of Plants. I have undertaken more than 30 scientific research projects, had more than 100 research papers published, and authorized 8 patents, and also a reviewer of more than 20 international academic journals. My research interests include natural product chemistry and bioorganic analysis. Our team proposed the strategy of "ligand fishing" for targeted analysis and rapid screening of active natural products. We are interested in developing new bio-organic analytical methods based on functionalized magnetic beads, carbon quantum dots, cell surface display, and microfluidic chips. In recent years, we focused on discovery of natural products from medicinal and edible plants possessing anti-Parkinson's disease and anti-Photoaging effects, by using the "ligand fishing" technique in combination with cellular and drosophila models.

Natural product chemistry

1. Polyphenolic glycosides with unusual four-membered ring possessing anti-Parkinson’s disease potential from black wolfberry. Phytochemistry, 2023, 213: 113775.

2. Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects. Journal of Agricultural and Food Chemistry, 2023, 71: 512–521.

3. Ligand fishing based on cell surface display of enzymes for inhibitor screening, Analytica Chimica Acta, 2021, 1156: 338359.

4. Fast identification of lipase inhibitors in oolong tea by using lipase functionalised Fe3O4 magnetic nanoparticles coupled with UPLC–MS/MS, Food Chemistry, 2015, 173: 521-526

5. Covalent immobilization of porcine pancreatic lipase on carboxyl-activated magnetic nanoparticles: Characterization and application for enzymatic inhibition assays, Materials Science and Engineering: C, 2014, 38: 278-285.

1. Research and development of polypeptides with anti-Parkinson's disease activity in Dilong, Sichuan Province Key Research and Development Project，2023.1–2024.12

2. Systematic mining, development and utilization of bioactive components in Salvia miltiorrhizae, Major Science and Technology Innovation Project of Chinese Academy of Sciences-Chengdu City Science and Technology Co-operation. 2021.12–2023.11

3. Surface display technology for the study of hypoglycemic active ingredients in medicinal plants, Sichuan Province Application Basic Key Research project，2017.1–2019.12

4. Establishment of natural compounds targeting Parkinson's disease proteins and screening for lead compounds，Chinese Academy of Sciences Strategic Bioresources Service Network Program, 2016.11–2018.6

5. Application of microfluidic chip electrophoresis-mass spectrometry methodology in the study of primordial germ cell development, "West Light" talent Scholarship Program, 2015.1–2018.12

6. Screening of small molecule enzyme inhibitors in traditional Chinese medicine with fluorescent magnetic nanoparticle probe, The National Natural Science Foundation of China, 2011.1–2015.12

7. Magnetic nanoparticle-based microsomal bioreactor for metabolic studies of traditional Chinese medicine, The National Natural Science Foundation of China, 2010.1–2013.12

8. Ligand fishing of active ingredients in traditional Chinese medicine by magnetic nanoparticle solid-phase extraction (SPE), The National Natural Science Foundation of China, 2008.1–2010.12