Chinese | CAS
Jian Sun
Title: Professor
Phone: 
Highest   Education:Ph.D.
Email: sunjian@cib.ac.cn

Education and Appointments:

B.Sc., Sichuan University, China, 1998-1992

M.Sc., Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, China, 1992-1995

Ph.D., Institute of Chemistry, Chinese Academy of Sciences, China, 1995-1998

 

 

Research Interest

Methodology development for organic synthesis, medicinal chemistry, and pharmacology

Public Services

Honors

Seleted Publication

  (1) X.-W. Liu, C. Wang,* Y. Yan, Y.-Q. Wang, J. Sun*, “Highly Enantioselective Hydrosilylation of 1,4-Benzooxazines:S-Chirality and C-Chirality Hybridized Catalyst Makes It Possible”, J. Org. Chem. 2013, 78, 6276-6280. 

  (2) Z. Wang*, C. Wang, L. Zhou, J. Sun*, “L-Pipecolinic Acid Derived Lewis Base Organocatalyst for Asymmetric Reduction of N-Aryl Imines by Trichlorosilane: Effects of the Side Amide Group on Catalytic Performances”, Org. Biomol. Chem. 2013, 11, 787-797. 

  (3) F. Pan, Z. Lei, H. Wang, H. Li, J. Sun*, Z.-J. Shi*, “Rhodium(I)-Catalyzed Redox-Economic Cross-Coupling of Carboxylic Acids with Arenes Directed by N-Containing Groups”, Angew. Chem. Int. Ed. 2013, 52, 2063-2067. 

  (4) L. Dong, T. Fan, C. Wang, J. Sun*, “One-pot formation of chiral polysubstituted 3,4-dihydropyrans via a novel organocatalytic domino sequence involving alkynal self-condensation”, Org. Lett. 2013, 15(1), 204-207. 

  (5) P. Zhang, C. Wang*, L. Zhou, J. Sun*, “Formation of Chiral α-Monofluorinated-β-amino Esters through Organocatalytic Asymmetric Reduction of α-Fluoro-β-enamino Esters by Trichlorosilane”, Chin. J. Chem. 2012, 30, 2636-2640. 

  (6) X.-W. Liu, Y. Yan, Y.-Q. Wang, C. Wang, J. Sun*, “Highly Enantioselective Reduction of β-Amino Nitroolefins with a Simple N-Sulfinyl Urea as Bifunctional Catalyst”, Chem. Eur. J. 2012, 18, 9204-9207. 

  (7) Wang Z.*, Pei D., Zhang Y., Wang C., Sun J*. “A Facile One-Pot Process for the Formation of Hindered Tertiary Amines”, Molecules 2012, 17(5), 5151-5163. 

  (8) Z. Lei, H. Li, Y. Li, X. Zhang, K, Chen, X. Wang, J. Sun*, Z.-J. Shi*, “Extrusion of CO from Aryl Ketones: Rhodium (I)-Catalyzed C-C Bond Cleavage Directed by a Pyridine Group”, Angew. Chem. Int. Ed. 2012, 51, 2609-2694. 

  (9) X. Cai, C. Wang, J. Sun*, “Organocatalytic Enantioselective Dipolar [3+2] Cycloaddition of Acetylenic Aldehydes with Nitrones for the Formation of Chiral 4-Isoxazolines”, Adv. Synth. Catal. 2012, 354, 359-363. 

  (10) C. Wang, F. Xie, N. Suthiwangcharoen, J. Sun*, Q. Wang*, “Tuning the optical properties of BODIPY dye through Cu(I) catalyzed azide-alkyne cycloaddition (CuAAC) reaction”, Sci. China Chem. 2012, 55, 125-130. 

  (11) An J, Gao Y, Wang J, Zhu Q, Ma Y, Wu J, Sun J*, Tang Y*. Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway. Biotechnology Letters 2012, 34(10):1781-1788. 

  (12) Zhao X, Chao Y, Wan Q, Chen X, Su P, Sun J*, Tang Y*. Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 gene expression”, Canadian Journal of Physiology and Pharmacology 2011, 89(12): 875-883. 

  (13) Ke Cheng, Tiantian Fan, Jian Sun*, “Chiral Phosphoric Acid Catalyzed Enantioselective Allylation of Aldehydes with Allyltrichlorosilane”, Chin. J. Chem. 2011, 29, 1669-1671. 

  (14) You-Cai Xiao, Chao Wang, Yuan Yao, Jian Sun*, Ying-Chun Chen*, “Direct Asymmetric Hydrosilylation of Indoles: Combined Lewis Base and Brnsted Acid Activation”, Angew. Chem. Int. Ed. 2011, 50, 10661-10664. 

  (15) X. Wu, Y. Li, C. Wang, L. Zhou, X. Lu, J. Sun*, “Chiral Lewis Base Catalyzed Highly Enantioselective Reduction ofN-Alkyl β-Enamino Esters with Trichlorosilane and Water”, Chem. Eur. J. 2011, 17, 2846-2848. 

  (16) Y. Li, K. Cheng, X. Lu, J. Sun*, “A Facile and Efficient Approach to N-Protected-b-Sulfinylenamines via C-Sulfinylation of Enamides and Enecarbamates”, Adv. Synth. Catal. 2010, 352, 1876-1880. 

  (17) Z. Wang, Z. Li, X. Lu, J. Sun*, Chiral N-formyl amino alcohol as Lewis basic organocatalyst for enantioselective hydrosilylation of ketimines”, Chin. Sci. Bull. 2010, 55, 1726-1728. 

  (18) P. Wu, D. Lin, X. Lu, J. Sun*, “Trimethylchlorosilane-promoted aza-Mannich Reaction of enecarbamates and aldimines”, Tetrahedron Lett. 2009, 50, 7249-7251. 

  (19) D. Lin, K. Cheng, X. Lu, J. Sun*, “Methyltrichlorosilane/DMSO: A Facile and Highly Efficient Recipe for the Chlorination of Enamides and Enecarbamates”, Synlett 2009, (18), 2961-2964. 

  (20) P. Wu, Z. Wang, M. Cheng, L. Zhou, J. Sun*, “Development of Highly Enantioselective New Lewis Basic N-Formamide Organocatalysts for Hydrosilylation of Imines with an Unprecedented Substrate Profile”, Tetrahedron 2008, 64, 11304-11312. 

  (21) C. Wang, X. Wu, L. Zhou, J. Sun*, “A Highly Enantioselective Organocatalytic Method for Reduction of Aromatic N-Alkyl Ketimines”, Chem. Eur. J. 2008, 14, 8789-8792. 

  (22) D. Pei, Y. Zhang. S. Wei, M. Wang, J. Sun*, “Rationally-Designed S-Chiral Bissulfinamides as Highly Enantioselective Organocatalysts for Reduction of Ketimines”, Adv. Synth. Catal. 2008, 350, 619-623. 

  (23) P. Wu, J. Sun*, “Facile Allylation of N-Boc and N-Cbz Imines with Allyltrichlorosilane Promoted by DMF”, Syn. Commun. 2008, 38, 1003-1010. 

  (24) L. Zhou, Z. Wang, S. Wei, J. Sun*, “Evolution of Chiral Lewis Basic N-Formamide as Highly Effective Organocatalyst for Asymmetric Reduction of Both Ketones and Ketimines with an Unprecedented Substrate Scope”, Chem. Commun.2007, (28), 2977 - 2979. 

  (25) H. Chen, Y. Wang, S. Wei, J. Sun*, “L-Proline Derived Triamine as Highly Stereoselective Organocatalyst for Asymmetric Michael Addition of Cyclohexanone to Nitroolefins”, Tetrahedron: Asymmetry 2007, 18, 1308-1312. 

  (26) Z. Wang, S. Wei, C. Wang, J. Sun*, Enantioselective Hydrosilylation of Ketimines Catalyzed by Lewis Basic C2-Symmetric Chiral Tetraamide”, Tetrahedron: Asymmetry 2007, 18, 705-709. 

  (27) D. Pei, Z. Wang, S. Wei, Y. Zhang, J. Sun*, “S-Chiral Sulfinamides as Highly Enantioselective Organocatalysts”,Org. Lett. 2006, 8(25), 5913-5915. 

  (28) Z. Wang, M. Cheng, P. Wu, S. Wei, J. Sun*, “L-Piperazine-2-Carboxylic Acid Derived N-Formamide as Highly Enantioselective Lewis Basic Catalyst for Hydrosilylation of N-Aryl Imines with an Unprecedented Substrate Profile”, Org. Lett. 2006, 8(14), 3045-3048. 

  (29) Z. Wang, X. Ye, S. Wei, P. Wu, A. Zhang, J. Sun*, “A Highly Enantioselective Lewis Basic Organocatalyst for Reduction of N-Aryl Imines with Unprecedented Substrate Spectrum”, Org. Lett. 2006, 8(5), 999-1001. 

  (30) C. Cheng, J. Sun*, C. Wang, Y. Zhang, S. Wei, F. Jiang, Y.-D. Wu*, “Protonated N’-benzyl-N’-prolyl Proline Hydrazide as Highly Enantioselective Catalyst for Direct Asymmetric Aldol Reaction”, Chem. Commun. 2006, (2), 215 - 217. 

  (31) Y. Wang, S. Wei, J. Sun*, “cis-4-Pyrrolidin-1-yl-L-Proline: A Highly Stereoselective Organocatalyst for the Direct Aldol Reaction”, Synlett 2006, (19), 3319-3323. 

  (32) C. Cheng, S. Wei, J. Sun*, “Trans-4-Hydroxy-L-Proline Hydrazide-Trifluoroacetic Acid as Highly Stereoselective Organocatalyst for the Asymmetric Direct Aldol Reaction of Cyclohexanone”, Synlett 2006, (15), 2419-2422. 

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