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Catalyst-free direct difunctionalization of alkenes with H-phosphine oxides and dioxygen: a facile and green approach to β-hydroxyphosphine oxides

Update time: 08/25/2016
A simple and catalyst-free method has been developed for the construction of β-hydroxyphosphine oxides through direct difunctionalization of alkenes with H-phosphine oxides and dioxygen under mild conditions. Preliminary mechanistic studies indicated that the hydroxyl oxygen atom of β-hydroxyphosphine oxide originated from the dioxygen and the present reaction might involve a radical process.