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Study of copper-Catalyzed Enantioselective 1,6-Boration of para-Quinone Methides and Efficient Transformation of gem-Diarylmethine Boronates to Triarylmethanes

Update time: 11/23/2015

Presented is the first enantioselective copper-catalyzed 1,6-conjugate addition of bis(pinacolato) diboron to para-quinone methides. The reaction proceeds with excellent yields and good to excellent enantioselectivities, and provides an attractive approach to the construction of optically active gem-diarylmehtine boronic esters. Additionally, the subsequent conversion of the derived potassium trifluoroborates into triarylmethanes with highly enantiospecificity was realized.

Prof.LIAO Jian from Chengdu Institute of Biology conducted this research.