This invention belongs to the biochemical engineering technology field. Firstly, inoculate the Lactobacillus Brevis AS 1.12 to the tomato juice medium; after anaerobic culture for 12 to 24 hours, centrifuge to collect bacterial cells, wash with saline water, and centrifuge again; disperse the cells in to 0.05M phosphate buffer solution, add substrate paeoniflorin and so on; after conversion for 2 to 24 hours, extraction with ethyl acetate, put the concentrated extract liquor to the dry conversion material extract, separate by the silica gel column chromatography, we can obtain the PM-1 from root of Paeonia lactiflora 

This invention is simple, easy to control, short cycle, low cost, high efficiency, environmentally friendly and so on; and it can solve the problems of raw materials on manufacturing the drugs of analgesic antispasmodic, anti-inflammatory, anti-stress ulcer, expansion of coronary vessels, antagonizing acute myocardial ischemia, as well as inhibiting platelet aggregation.